It’s important to not misunderstand the information in the various different clinical trials … Milk thistle can also change how your body metabolizes certain drugs, and while the drug interaction may not be harmful, milk thistle can reduce the efficacy of your medication. In patients with active rheumatoid arthritis, the same effects on apoptosis, proliferation, and cytokine production were noted. Patients were randomly assigned to also receive silymarin 140 mg 3 times daily or placebo. Both silibinin and silymarin exerted activity against Candida albicans, Candida tropicalis, and Candida krusei.de Oliveira 2015 Additionally, silibinin demonstrated a membrane-damaging effect as well as antibiofilm activity on C. albicans.Yun 2017 Dehydroisosilybin A, a component of milk thistle, demonstrated synergistic effects with amphotericin B against Leishmania.Olías-Molero 2018 Another study found silybin may be an efflux pump inhibitor; the compound eliminated the plasmid from methicillin-resistant S. aureus (MRSA) 41577, restoring the bacteria's sensitivity to antibiotics. During radiation therapy, scores significantly increased in both the silymarin and placebo groups, but the silymarin group experienced a delay in the development and progression of oral mucositis.Elyasi 2016, The effect of silymarin on capecitabine-induced hand-foot syndrome was evaluated in 40 patients with GI cancer in a double-blind, randomized, placebo-controlled trial. It is used for canines as well. In one study in children with acute lymphoblastic leukemia (ALL), silibinin (as Siliphos) was administered for 28 days and compared to placebo. All rights reserved. Milk thistle for dogs can help their liver more effectively filter … In a multicenter, double-blind, placebo-controlled trial, 154 patients with chronic hepatitis C and elevated ALT levels who were unsuccessfully treated with interferon, silymarin 420 mg or 700 mg 3 times daily for 24 weeks did not significantly reduce ALT levels.Fried 2012 In a study of children 5 to 16 years of age with nonalcoholic fatty liver disease, silymarin given for 12 weeks improved fatty liver infiltration, liver function tests, and triglyceride levels; however, LDL and HDL cholesterol levels were not altered.Famouri 2017, Milk thistle may be useful in acute hepatotoxicity due to amatoxin poisoning from ingestion of Amanita phallides or other Aminata mushrooms. Milk thistle, also known as Silybum Marianum is an herb that has been used for thousands of years by humans for its powerful medicinal properties. Milk Thistle Dosage for Dogs As the milk thistle concentration varies from one supplement to another, it is recommended to consult your bet for deciding the dosage for your pet. There’s some evidence that milk thistle can treat cirrhosis and chronic hepatitis, which can be caused by alcohol abuse, autoimmune disease, or viruses. It is a fact that herbs have been used by humans since time immemorial. It’s unclear what benefits, if any, it may have in the body, but it’s sometimes used as a natural treatment for things including cirrhosis, jaundice, hepatitis, and gallbladder disorders. Since milk thistle may lower blood sugar, people with diabetes should check with their doctor before taking the herb as it may make their blood sugar fall too low. We comply with the HONcode standard for trustworthy health information -, https://nccih.nih.gov/health/milkthistle/ataglance.htm, https://clinicaltrials.gov/ct2/results?cond=&term=milk+thistle&cntry=&state=&city=&dist=. Milk thistle has been used in alternative medicine as a possibly effective aid in treating heartburn, or seasonal allergy symptoms. Although it was once relegated to “crunchy” circles, people widely use the herb to treat a variety of health problems. However, median ALT levels were not significantly different between groups. ", National Center of Complementary and Alternative Medicine (NCCAM): "Milk Thistle," “Herbs at a Glance: Milk thistle.”, Medicinenet.com: "Generic Name: Milk Thistle – Oral.". However, when silymarin was combined with these agents, serum indices and hepatic markers were reduced. Milk thistle is not recommended for children. Quality and active ingredients in supplements may vary widely from maker to maker. Milk thistle, a herb that has long been used for treating liver diseases in humans, is also found to be useful for animals. While milk thistle has been traditionally used in pregnant and breastfeeding women, its safety is unknown. People who are allergic to artichokes, kiwi, ragweed, daisies, marigolds, and chrysanthemums are at higher risk. Although the majority of studies were of poor quality, the positive synergistic effect is an important finding that can help inform future clinical studies.Wei 2013, In patients with hepatitis C, beneficial effects have not been noted with use of silymarin. Silymarin was well tolerated.Shahbazi 2015, In a study of patients with liver cirrhosis, silymarin did not exert protective effects against contrast-induced nephrotoxicity.Kuo 2018, Milk thistle is reported to possibly be effective in dyslipidemia due to a reduction in hydroxymethylglutaryl coenzyme A (HMG CoA) reductase as well as de novo synthesis in cholesterol.Stolf 2017, In a rat model of hereditary hypertriglyceridemia, 4 weeks of silymarin administration significantly reduced triglyceride and total cholesterol levels, and increased high-density lipoprotein (HDL) cholesterol levels.Poruba 2015, In a triple-blind, randomized, placebo-controlled trial in adults with at least a 6-month history of type 2 diabetes (N=40), statistically significant improvements in some lipid parameters were observed in those receiving a standardized silymarin extract (490 mg/day for 45 days) compared to placebo. 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